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Table of Contents Features LASER SURGERY/CANCER TREATMENT: Real-time interactivity enhances interstitial brain tumor therapy Laser interstitial thermal therapy (LITT) is a minimally invasive, low cost, and effective approach to neurosurgery. CELL BIOLOGY/BIOMEDICAL IMAGING: Ultraviolet becomes accessible UV lasers are attractive for excitation of fluorophores growing in popularity for DNA analysis and calcium imaging applications. OPHTHALMOLOGY/MEDICAL IMAGING: Retinal imaging advances research, disease diagnosis Recent instrumentation progress is enabling superior imaging of the retina in both laboratory animals and humans. Departments BioOptics Breakthroughs Tumors fluoresce before turning deadly A Vanderbilt University (Nashville, TN) team has developed novel imaging agents able to light up tumors before they turn deadly, monitor a tumor's transition from premalignancy to aggressive growth, and to define tumor margins during surgical removal. Molecular structure discovery promises rainbow of new probes "We need to have a lot of colors to study events simultaneously in one cell," says Vladislav Verkhusha of Albert Einstein College of Medicine at Yeshiva University (New York, NY). LEDs system promising for oral cancer detection in developing countries More than two-thirds of cases and three-quarters of deaths due to oral cancer occur in developing countries. Nanoscale MRI depends on AFM, fluorescence "It's by far the most sensitive MRI imaging technique that has been demonstrated," says Raffi Budakian, assistant professor of physics at the University of Illinois at Urbana-Champaign, commenting on combining atomic force microscopy (AFM) with magnetic resonance imaging (MRI)?magnetic resonance force microscopy (MRFM). News & Views LEGISLATION/R&D/LASER THERAPY: How the two sides of healthcare reform affect biophotonics The landmark healthcare legislation Congress passed in March 2010 promises to boost research and innovation, but paying for those programs may mean medical device manufacturers take a hit to their bottom lines (see sidebar "Paying for reform"). LASER SURGERY/TISSUE REPAIR: Laser tissue bonding aims to replace suturing Researchers at Tel Aviv University (Tel Aviv, Israel) are using lasers to both close and heal tissue wounds. BIOPHOTONICS ROADMAPPING/CONFERENCES AND WORKSHOPS: Bio-optics lollapalooza in Quebec: Five events in one What happens when five biophotonics-focused events take place in the same city during the same week? MULTIPHOTON MICROSCOPY/FLUORESCENT PROTEINS: New approach overcomes limitations of two-photon dual-color imaging Two-photon dual-color imaging of tissues and cells labeled with fluorescent proteins (FPs) is a powerful microscopy tool. PHOTODYNAMICS/MARKET GROWTH: Medical and dental applications growing for photocatalysts Photocatalysts-catalysts that use photons to activate chemical reactions-generally have superior oxidizing properties and superhydrophilicity. Product Showcase Components Systems Products The Deschutes BSI series of backside-illuminated avalanche photodiodes (APDs) promises superior responsivity and lower capacitance compared with frontside-illuminated APDs End Result Laser hair removal continues to top charts According to the American Society of Plastic Surgeons (ASPS), 12.5 million cosmetic plastic surgery procedures were performed in the U.S. in 2009–down 1% from 2008 and up 69% since 2000. Columns Editor's Column Optics and photonics + X = wow A major trend in the field of microscopy is taking center stage. Inside Instrumentation Seeing more sequences: Driving DNA discovery Popping open a door on the left-hand side of an instrument, Scott Hunicke-Smith reveals the imaging end of a DNA-sequencing machine.

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