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Table of Contents Features DNA SEQUENCING/GENOMICS: Toward personalized medicine: 3G DNA sequencing Just on the horizon, new DNA sequencing systems promise real-time processing at reduced cost with single-molecule resolution LASER TISSUE INTERACTION/CELL BIOLOGY: THz in biology and medicine: Can neurons sense millimeter waves? Work to determine the impact of Terahertz radiation on biological systems olds promise for noninvasive neuronal response control IN-VIVO IMAGING/MOLECULAR IMAGING: Speeding the path to clinical trials: optical imaging in drug development Optical molecular imaging is increasingly augmenting standard, non-optical approaches–enabling the drug development process with efficiency, economy, and insight. MEASUREMENT STANDARDS/SUPER-RESOLUTION MICROSCOPY: Quantifying fluorescence EMCCD technology, which revolutionized the life sciences by enabling visualization of low-light events, is quantitative. But EMCCD's standard unit of measure is variable. Departments Breakthroughs Seek and destroy tumors, and report, "mission accomplished" Scientists at the University of California, Berkeley have created nanoprobes that not only selectively seek and destroy tumor cells, but also report the status of their work. PDT proves effective for early-stage oral cancers Researchers at the Henry Ford Health System (Detroit, MI) have concluded a study that finds photodynamic laser therapy (PDT) effective for treating early-stage (Tis-T2N0M0) squamous cell carcinomas of the oral cavity and oropharynx. Laser-induced nanobubbles kill cancer cells When short laser pulses strike gold nanoparticles, nanobubbles form–and Rice University (Houston, TX) scientists have found that they can tune the lasers to create either small, bright bubbles that are visible but harmless, or large bubbles that burst cells. Low-cost approach enables high-res, hi-speed motion capture The ability to capture high-quality still images that correspond exactly to high-speed video is very desirable and currently very expensive. Light switch turns paralysis on and off As described in a paper in the Journal of the American Chemical Society (2009, 131 (46), pp 16644–16645), Neil Branda and colleagues at Simon Fraser University (Burnaby, BC, Canada) have demonstrated an on-off "switch" that, when exposed to ultraviolet light, holds animals in paralysis even when the light is turned off. News & Views BIOSCIENCE BUDGET/PUBLIC POLICY: Biomedical research funding up for 2011 It could have been worse. BIOMEDICAL IMAGING/DISEASE THERAPY: Hot at BiOS: Invited talks discuss important research What's hot in San Francisco? BIOMEDICAL IMAGING/LASER LIGHT SOURCES: BiOS exhibits feature high-power lasers, innovative imaging In the exhibit hall at the Biomedical Optics Symposium (BiOS) that ran as part of Photonics West 2010 (San Francisco, CA, January 23-28), high power was a theme. BIOPHOTONICS COMMERCIALIZATION: Changes in FDA device approval process could be costly The winds of change are blowing at the Food and Drug Administration's (FDA) Center for Devices and Radiological Health (CDRH). OPTOACOUSTICS/MEDICAL IMAGING STANDARDS: Getting quantitative data from photoacoustic images Photoacoustic imaging is an emerging biomedical imaging modality capable of visualizing optically absorbing structures with high resolution (sub-50 microns) to centimeter depths in optically scattering soft tissue. Product Showcase Components & Systems Products A new coherent anti-stokes Raman scattering (CARS) optimized supercontinuum generation fiber device designed for use with 800 nm femtosecond lasers, the SCG-800-CARS contains 12 cm, highly nonlinear photonic crystal fiber. End Result Celebrating the laser I could foresee a lot of things," said Charles H. Townes, speaking on the occasion of the 50th anniversary of the first working laser. Columns Editor's Column As BiOS grows... Attendance at the largest annual event in biophotonics grew 19% this year over 2009. According to the SPIE, the Biomedical Optics Symposium (BiOS) at Photonics West 2010 drew 5,448 participants, including 3,191 conference attendees, 646 exhibition-only visitors, and 1,611 exhibitor representatives from 179 exhibiting companies. Inside Instrumentation Nanotech: a revolution for resolution Nanotechnology is revolutionizing optics in general," says Srinivas Sridhar, a physicist at Northeastern University (Boston, MA).

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